THC initiates brain cancer cells to destroy themselves
THC, the active ingredient in marijuana, causes brain cancer cells to undergo a process called autophagy in which cells feed upon themselves, according to a study conducted by Guillermo Velasco and colleagues at Complutense University in Spain. Using mice designed to carry human brain cancer tumors, the researchers found that the growth of the tumors shrank when the animals received THC. The study also involved two patients with glioblastoma multiforme, a highly aggressive form of brain cancer. Both patients had been enrolled in a clinical trial designed to test THC's potential as a cancer therapy. The researchers used electron microscopes to analyze brain tissue taken before and after a 26- to 30-day THC treatment regimen. They found that THC eliminated the cancer cells while leaving healthy cells intact. In addition, in what they described as a "novel discovery," the specific signalling route by which the autophagy process unfolds was isolated.
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